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Cannonballs for Kayne Funds DIPG Research at Cincinnati Children's Hospital Medical Center


Pictured left to right: Dr. Ralph Salloum, Dr. Melissa Mark, Kirsten Finley, Curtis Finley, Dementor_the_Moose (Instagram), Keagan Finley, Christel Murphy and Al Rich


Rachid Drissi PhD; photo courtesy of CCHMC



Excitedly announcing our very first research grant thanks to all of you! 


Partnering with Cincinnati Children’s Hospital Medical Center and Principal Investigator Rachid Drissi PhD of the Brain Tumor Center, the research objective of this work is on “Investigation of the Radiation Resistance in DIPG through Radiogenomics.” Dr. Drissi will investigate and evaluate genetic and epigenetic mediators of differential radiation therapy response and toxicity as well as conduct in vitro studies to examine DNA damage signaling pathways post-radiation in wild type, H3.1K27M, and H3.3K27M DIPG cell lines.

Despite the advances in understanding the biology of DIPG, mechanisms of response or resistance to therapy have not been well delineated and are critical to the development of effective therapies for this vulnerable population. This study will harness understanding of radiation therapy response in DIPG with a goal of rapid clinical translation to improve survival for children with this devastating disease.


Dr. Drissi hypothesizes that H3.3K27M mediates radiation therapy resistance in DIPG through genetic and epigenetic alterations of DNA damage response.  It is our desire to fully fund this $150,000 study and with your help we will be successful. 


The Cannonballs for Kayne Foundation is an emerging foundation, striving for excellence in research and is committed to improving the future of those afflicted by pediatric brain cancer, with emphasis on DIPG. Together we will MAKE WAVES!


“That they do good, that they be rich in good works, that they be ready to distribute, willing to communicate.” 1 Timothy 6:18

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